大島 剛

助教
大島 剛(おおしま ごう)
2004年 慶應義塾大学医学部卒
     日本外科学会専門医
     日本消化器外科学会専門医
     日本内視鏡外科学会技術認定医
     日本肝臓学会肝臓専門医
     日本消化器内視鏡学会専門医

専門領域
肝胆膵領域癌、低侵襲手術、腹腔鏡下肝切除、腹腔鏡下膵切除、転移性肝腫瘍、トランスレーショナルリサーチ
コメント
肝胆膵脾領域における外科治療が専門です。腹腔鏡を用いた低侵襲手術に注力しています。高度な技能を要する本領域の手術には、肝胆膵だけでなく胃や大腸を含む消化器臓器全般に対する総合的な実力が必要です。これまでの専門的かつ臓器横断的な経験を生かして「根治を目指す積極性」と「できるだけ体の負担を小さくする低侵襲性」のバランスがとれた治療を心がけています。

経歴

2004年東京都済生会中央病院 初期臨床研修医
2006年慶應義塾大学医学部外科学教室入局
永寿総合病院外科
2007年東京歯科大学市川総合病院外科
2008年慶應義塾大学病院一般・消化器外科
2011年永寿総合病院外科
2013年米国シカゴ大学外科 研究員
2016年東京医科大学八王子医療センター消化器外科・移植外科
2017年慶應義塾大学病院 一般・消化器外科 助教

主たる研究内容


資格


所属学会


受賞歴

2018年刀林賞
2018年ドイツモニカ財団奨学生
2017年第24回 外科侵襲とサイトカイン研究会 会長賞
2014年第16回 前田賞
2010年Young Investigatory - Full Bursary at 45th Annual Meeting of International Liver Congress 2010 by EASL (European Association for the Study of the Liver)

助成金

2018年文部科学省科学研究費 若手研究
「オリゴ型大腸癌肝転移における遺伝子発現解析についての検討」
2016年東京医科大学研究助成金 学長裁量経費

論文

1.Oshima G, Poli EC, Bolt MJ, Chlenski A, Forde M, Jutzy JMS, Biyani N, Posner MC, Pitroda SP, Weichselbaum RR, Khodarev NN. DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs. Cancer Res. 79(3):650-662, 2019.
2.Oshima G, Guo N, He C, Stack ME, Poon C, Uppal A, Wightman SC, Parekh A, Skowron K, Posner MC, Lin W, Khodarev NN, WeichselbaumIn RR. In vivo delivery and therapeutic effects of a microRNA on colorectal liver metastases. Mol Ther. S1525-0016(17)30164-8. 2017.
3.Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones. J Vis Exp, 30(117): 2016.
4.Oshima G, Wightman SC, Uppal A, Stack ME, Pitroda SP, Oskvarek JJ, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Imaging of tumor clones with differential liver colonization. Sci Rep, 22;5:10946, 2015.
5.Oshima G, Shinoda M, Tanabe M, Ebinuma H, Nishiyama R, Takano K, Yamada S, Miyasho T, Masugi Y, Matsuda S, Suda K, Fukunaga K, Matsubara K, Hibi T, Yagi H, Hayashida T, Yamagishi Y, Obara H, Itano O, Takeuchi H, Kawachi S, Saito H, Hibi T, Maruyama I, Kitagawa Y: Increased plasma levels of high mobility group box 1 in patients with acute liver failure. Eur Surg Res, 48(3): 154-162, 2012.
6.Oshima G, Shinoda M, Tanabe M, Masugi Y, Ueno A, Takano K, Kitago M, Itano O, Kawachi S, Ohara K, Oda M, Tanimoto A, Sakamaoto M, Kitagawa Y: Primary hepatic cancers with multiple pathological features in a patient with hepatitis C: report of a case. Int Surg, 97: 17-22, 2012.
7.Oshima G, Itano O, Matsui H, Chiba N, Ishikawa H, Koyama Y, Miyakita M, Yuasa Y: Usefulness of multi-slice CT in a case with internal fistulas in Crohn's disease. Hepatogastroenterology, 55(86-87): 1664-5, 2008.
8.Hepatopancreatoduodenectomy for perihilar cholangiocarcinoma following laparoscopic total gastrectomy. Chiba N, Gunji T, Ozawa Y, Hikita K, Okihara M, Sano T, Tomita K, Oshima G, Abe Y, Kawachi S. Asian Journal of Endoscopic Surgery, 2017, in press
9.Wong AC, Watson SP, Pitroda SP, Son CH, Das LC, Stack ME, Uppal A, Oshima G, Khodarev NN, Salama JK, Weichselbaum RR, Chmura SJ, Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT). Cancer, 122(14): 2242-50, 2016
10.Wightman SC, Uppal A, Pitroda S, Ganai S, Burnette B, Stack ME, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signaling drives metastasis development and poor clinical outcome. Br J Cancer, 14;113(2):327-35, 2015
11.Itano O, Oshima G, Kitago M, Suzuki K, Hayatsu S, Shinoda M, Abe Y, Hibi T, Yagi H, Ikoma N, Aiko S, Kitagawa Y. Harness Traction Technique (HARNESS): Novel method for controlling the transection plane during laparoscopic hepatectomy, Surg Laparosc Endosc Percutan Tech, 25(4):e117-21, 2015.
12.Itano O, Oshima G, Minagawa T, Shinoda M, Kitago M, Abe Y, Hibi T, Yagi H, Ikoma N, Aiko S, Kawaida M, Masugi Y, Kameyama K, Sakamoto M, Kitagawa Y. Novel strategy for laparoscopic treatment of pT2 gallbladder carcinoma. Surgical Endoscopy, 29(12):3600-7, 2015.
13.Itano O, Ikoma N, Takei H, Oshima G, Kitagawa Y. The Superficial Precoagulation, Sealing, and Transection Method: A "Bloodless" and "Ecofriendly" Laparoscopic Liver Transection Technique, Surg Laparosc Endosc Percutan Tech. 25(1): e33-6, 2015.
14.Uppal A, Wightman SC, Mallon S, Oshima G, Pitroda SP, Zhang Q, Huang X, Darga TE, Huang L, Andrade J, Liu H, Ferguson MK, Greene GL, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR. 14q32-encoded microRNAs mediate an oligometastatic phenotype. Oncogarget, 28;6(6):3540-52, 2015.
15.Tanaka M, Shinoda M, Takayanagi A, Oshima G, Nishiyama R, Fukuda K, Yagi H, Hayashida T, Masugi Y, Suda K, Yamada S, Miyasho T, Hibi T, Abe Y, Kitago M, Obara H, Itano O, Takeuchi H, Sakamoto M, Tanabe M, Maruyama I, Kitagawa Y. Gene transfer of high-mobility group box 1 box-A domain in a rat acute liver failure model. J Surg Res, 194(2): 571-80, 2015.
16.Ikoma N, Itano O, Oshima G, Kitagawa Y. Laparoscopic liver mobilization: tricks of the trade to avoid complications. Surg Laparosc Endosc Percutan Tech, 25(1): e21-3, 2015.
17.Ikoma N, Itano O, Oshima G, Chiba N, Maeda S, Koyama Y, Aiko S, Kitagawa Y. Age-specific determinants of the safety of laparoscopic colectomy in elderly patients with colorectal cancer. American Surgeon, 80(4): 105-107, 2014.
18.Nishiyama R, Shinoda M, Tanabe M, Oshima G, Takano K, Miyasho T, Fuchimoto Y, Yamada S, Inoue T, Shimada K, Suda K, Tanaka M, Hayashida T, Yagi H, Kitago M, Obara H, Itano O, Takeuchi H, Kawachi S, Maruyama I, Kitagawa Y. Hemoadsorption of high-mobility group box chromosomal protein 1 using a column for large animals. Eur Surg Res, 51(3-4): 181-190, 2014.
19.Suzuki K, Itano O, Oshima G, Osaku M, Asanuma F, Kitagawa Y: Modified laparoscopic splenic vessel-preserving distal pancreatectomy: matador assistance and peel-away technique. World J Surg, 38(5): 1205-10, 2014.
20.Ikoma N, Itano O, Oshima G, Shah SK, Fukuhara S, Kitagawa Y, Laparoscopic hepatectomy is easier in repeated hepatectomy. Journal of the Society of Laparoendoscopic Surgeons, e2014.00202, 2014
21.Kadota Y, Shinoda M, Tanabe M, Tsujikawa H, Ueno A, Masugi Y, Oshima G, Nishiyama R, Tanaka M, Mihara K, Abe Y, Yagi H, Kitago M, Itano O, Kawachi S, Aiura K, Tanimoto A, Sakamaoto M, Kitagawa Y: Concomitant pancreatic endocrine neoplasm and intraductal papillary mucinous neoplasm: a case report and literature review. World J Surg Oncol, 11: 75, 2013.
22.Wada T, Itano O, Oshima G, Chiba N, Ishikawa H, Koyama Y, Du W, Kitagawa Y: A male case of an undifferentiated carcinoma with osteoclast-like giant cells originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. A case report and review of the literature. World J Surg Oncol, 9: 100, 2011.
23.Ono Y, Kawachi S, Hayashida T, Wakui M, Tanabe M, Itano O, Obara H, Shinoda M, Hibi T, Oshima G, Tani N, Mihara K, Kitagawa Y: The influence of donor age on liver regeneration and hepatic progenitor cell populations. Surgery, 150(2): 154-61, 2011.
24.Itano O, Chiba N, Maeda S, Matsui H, Oshima G, Wada T, Nakayama T, Ishikawa H, Koyama Y, Kitagawa Y: Laparoscopic-assisted limited liver resection: technique, indications and results. J Hepatobiliary Pancreat Surg, 16(6): 711-9, 2009.

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